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P olyclone provides custom screening services for small molecule validation. Our screening services are both in silico and in vitro.


W e employ our in silico engineering framework & screening algorithms to address requirements of lead identification and optimization projects. Our focus is to address specific challenges that come up in lead based research and we do not take up complete high throughput screening projects. Some of the questions we help answer are:

  • Where to modify a small molecule (drug or lead molecule) to improve the binding affinity or the activity of the molecule?
  • What is the predicted activity of the molecule for which the target or mechanism of action is not known?
  • Is it possible to identify metabolic transformations related to cytochrome- of a drug or a compound?
  • Is it possible to identify off-target binding of a given compound?

P olyclone provides custom screening services for small molecule validation. Our screening services are both in silico and in vitro.


W e provide custom cell and stem cell based assays for screening of targets & compounds . With cross-functional expertise in cell and molecular biology, we are able to offer a host of custom assays depending on the nature of the customer requirements. Our capabilities include:

  • Primary culture
  • Stem cell based culture
  • Stem cell isolation and differentiation
  • Differentiation assays
  • Stable cell line development
  • Cell proliferation and apoptosis assays
  • Metabolic assays

Case studies
> Cell based studies for comparison of transfection reagents